Micro and Nano-Scale Technologies for Cell Mechanics

Author:

Unal Mustafa1,Alapan Yunus12,Jia Hao3,Varga Adrienn G.4,Angelino Keith5,Aslan Mahmut12,Sayin Ismail24,Han Chanjuan6,Jiang Yanxia1,Zhang Zhehao5,Gurkan Umut A.1278

Affiliation:

1. Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA

2. Case Biomanufacturing and Microfabrication Laboratory, Case Western Reserve University, Cleveland, USA

3. Department of Biology, Case Western Reserve University, Cleveland, USA

4. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, USA

5. Department of Civil Engineering, Case Western Reserve University, Cleveland, USA

6. Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, USA

7. Department of Orthopaedics, Case Western Reserve University, Cleveland, USA

8. Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA

Abstract

Cell mechanics is a multidisciplinary field that bridges cell biology, fundamental mechanics, and micro and nanotechnology, which synergize to help us better understand the intricacies and the complex nature of cells in their native environment. With recent advances in nanotechnology, microfabrication methods and micro-electro-mechanical-systems (MEMS), we are now well situated to tap into the complex micro world of cells. The field that brings biology and MEMS together is known as Biological MEMS (BioMEMS). BioMEMS take advantage of systematic design and fabrication methods to create platforms that allow us to study cells like never before. These new technologies have been rapidly advancing the study of cell mechanics. This review article provides a succinct overview of cell mechanics and comprehensively surveys micro and nano-scale technologies that have been specifically developed for and are relevant to the mechanics of cells. Here we focus on micro and nano-scale technologies, and their applications in biology and medicine, including imaging, single cell analysis, cancer cell mechanics, organ-on-a-chip systems, pathogen detection, implantable devices, neuroscience and neurophysiology. We also provide a perspective on the future directions and challenges of technologies that relate to the mechanics of cells.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biotechnology

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