High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma
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Published:2021-12-07
Issue:12
Volume:101
Page:adv00613
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ISSN:1651-2057
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Container-title:Acta Dermato-Venereologica
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language:
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Short-container-title:Acta Derm Venereol
Author:
Xu Bufang,Liu Fengjie,Gao Yumei,Sun Jingru,Li Yingyi,Lin Yuchieh,Liu Xiangjun,Wen Yujie,Yi Shengguo,Dang Jingyang,Tu Ping,Wang Yang
Abstract
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, cutaneous T cell lymphoma may manifest aggressive clinical behaviour and lead to a poor prognosis. The mechanism of disease progression in cutaneous T cell lymphoma remains unknown. This study, based on a large clinical cohort, found that IKZF2, an essential transcription factor during T cell development and differentiation, showed stage- dependent overexpression in the malignant T cells in mycosis fungoides lesions. IKZF2 is specifically over- expressed in advanced-stage mycosis fungoides lesions, and correlates with poor prognosis. Mechanistically, overexpression of IKZF2 promotes cutaneous T cell lymphoma progression via inhibiting malignant cell apoptosis and may contribute to tumour immune escape by downregulating major histocompatibility complex II molecules and up-regulating the production of anti-inflammatory cytokine interleukin-10 by malignant T cells. These results demonstrate the important role of IKZF2 in high-risk cutaneous T cell lymphoma and pave the way for future targeted therapy.
Publisher
Medical Journals Sweden AB
Subject
Dermatology,General Medicine
Cited by
2 articles.
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