Author:
Woo Yu Ri,Cho Minah,Han Kyung Do,Cho Sang Hyun,Lee Ji Hyun
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with bimodal incidence peaks in early childhood and middle-aged and older adults. Few studies have focused on the risk of dementia in AD. The aims of this study were to analyse the incidence, and risk factors for dementia in patients with AD. This nationwide population-based retrospective cohort study enrolled 38,391 adults ≥ 40 years of age with AD and 2,643,602 controls without AD from the Korean National Health Insurance System (NHIS) database from 2009 to 2016. The cumulative incidence probability of all-cause dementia, Alzheimer’s disease, or vascular dementia at 8 years was 50, 39, and 7 per 1,000 person-years in patients with AD, respectively. The adjusted risks of all-cause dementia (hazard ratio (HR), 1.072; 95% confidence interval (95% CI) 1.026–1.120), and Alzheimer’s disease (HR 1.051; 95% CI 1.000–1.104) were increased in patients with AD. The effect of AD on the development of all-cause dementia and Alzheimer’s dementia varied according to age and diabetes mellitus (all p for interaction, < 0.05). The risks of all-cause dementia and Alzheimer’s disease were increased in patients with AD. Management of modifiable risk factors is important for preventing dementia in patients with AD.
Publisher
Medical Journals Sweden AB
Subject
Dermatology,General Medicine
Reference74 articles.
1. Prince MJ, Guerchet MM, Prina M. The epidemiology and impact of dementia: current state and future trends. WHO Thematic Briefing. Geneva: World Health Organization, 2015.
2. Choi YJ, Kim S, Hwang YJ, Kim C. Prevalence of dementia in Korea based on hospital utilization data from 2008 to 2016. Yonsei Med J 2021; 62: 948.
3. https://doi.org/10.3349/ymj.2021.62.10.948
4. Prince MJ, Wimo A, Guerchet MM, Ali GC, Wu Y-T, Prina M. World Alzheimer Report 2015 - the global impact of dementia: an analysis of prevalence, incidence, cost and trends. London: Alzheimer's Disease International, 2015.
5. Pasqualetti G, Brooks DJ, Edison P. The role of neuroinflammation in dementias. Curr Neurol Neurosci Rep 2015; 15: 17.
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