Down/regulation of epidermal growth factor receptors by dithranol.
-
Published:1993-02-01
Issue:1
Volume:73
Page:37-40
-
ISSN:1651-2057
-
Container-title:Acta Dermato-Venereologica
-
language:
-
Short-container-title:Acta Derm Venereol
Author:
Kemény L,Michel G,Arenberger P,Ruzicka T
Abstract
Dithranol is highly effective in the treatment of psoriasis, but the exact mechanism of action is not known. Since persistent expression of epidermal growth factor (EGF) receptors in psoriatic epidermis is assumed to have pathogenetic significance, we have studied the effects of dithranol on EGF binding to the human epidermal cell line SCL/II. After treatment of cells with dithranol or its therapeutically inactive oxidation product, danthrone, radioligand binding assays were performed with 125I/EGF. In therapeutically active concentrations (0.25/1 micrograms/ml) dithranol induced a decrease in EGF binding in a dose dependent manner. Danthrone was inactive. The inhibition occurred after a latency period of 6 h and reached its maximum at 24 h. At the concentration of 1 microgram/ml, the drug led to approximately a 70% decrease in the number of specific high/affinity EGF receptors (Bmax), whereas receptor affinity (Kd) showed no change. The down/regulation of EGF receptors on epidermal cells by dithranol may contribute to its antipsoriatic action.
Publisher
Medical Journals Sweden AB
Subject
Dermatology,General Medicine
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献