DIABETES MELLITUS TYPE 2 CORRECTION, CHANGES IN C-PEPTIDEMIA AND INSULINEMIA INCONNECTION WITH ILEODUODENOPLASTY

Abstract

Purpose of the study. The diabetes move changes estimate and c-peptidemia and insulinemia levels changes in connection with ileoduodenoplasty. Materials and methods. C-peptiemia and insulinemia were estimated in 45 patients with diabetes mellitus type 2. There were 20 men, 25 women, mean (M ± m) age 27,4 ± 9,5 years. Body mass index was from 23,4 to 61,4 kg/cm 2 . For glycemia correction pill medication use 12 patients, insulin injection 18, first revealed diabetes or insulin resistance with poorly corrected hypertension and cardiac insufficiency of 2 stage have 15 patients. Mean (M ± m) diabetic duration was 15,1 ± 7,7 years. Results. At 3 weeks since surgery glycemia correction by means of metformin was necessary in 6 patients, other do not need any diabetes correction.In terms 1–3, 4–6, 7–21 day, 22 day – 3 months, 3–12 months since surgery mean values of studied hormones declined gradually. In spite of this, declining in hormones level were unproportional one to another, in some patients it increases or changes in inverse mode: raising in insulinemia coincidence with decline in c-peptidemia and vice versa. Conclusion. Performing of ileoduodenoplasty lead to disappear of insulin resistance in few days since surgery.In term 3 weeks since surgery steady compensation of diabetes mellitus 2 type occur. Ambiguous changes in c-peptidemia and insulinemia levels both in early and late terms since surgery already not in equivalence with glycemia point out at its interrelation with other regulators of food consumption. Keywords: diabetes mellitus type 2 surgical compensation, ileoduodenoplasty, c-peptidemia and insulinemia changes.