Affiliation:
1. Ural State Medical University
Abstract
Background. The early onset of nephropathies creates certain risk of early chronic kidney disease development with loss of function (especially in children with unfavorable intrauterine period), renal tissue dysplasia, congenital malformations and/or urodynamic disorders.Objective. The aim of the study is to evaluate the role of ontogenesis factors in nephropathies development in tender-age infants with specification of the course features and kidneys morphometric parameters.Methods. Cohort study was conducted. The study group included 69 children aged from 0 to 36 months with changes in the kidneys (compared to age-specific ones) according to ultrasound and/or urinary syndrome (leukocyturia, bacteriuria, proteinuria, etc.). The control group included 35 relatively healthy children of the same age. Comparative analysis of antenatal and postnatal medical history was carried out in both groups, as well as comparison of morphometric indicators of the urinary system organs at neonatal ultrasound screening. Pathological process onset was also considered in the group of children with nephropathies. The study was conducted during 2018–2021.Results. Possible predictors of pathology process in children with early onset of nephropathies are: 1) maternal diseases: urinary system disorders (OR = 4.99), blood pathology, mainly anemia of the 2nd–3rd grade (OR = 6.94), cardiovascular system diseases (OR = 10.26), inflammatory diseases of genital tract (OR = 10.61); 2) pregnancy failures: gestational diabetes mellitus (OR = 7.24), preeclampsia and eclampsia (OR = 4.40); placental pathology (OR = 17.0), and fetoplacental insufficiency (OR = 7.61); 3) feeding features: early conversion to breast-milk substitutes (OR = 2.81). 50.7% of children of this group has shown persistent urodynamic disorders already at first months of life according to ultrasound data, as well as signs of bloated kidneys. It was shown that the inflammatory process manifestation associated with aggravated perinatal history and congenital defects occurs significantly earlier — 2 months, and without any defects — 4 months (p = 0.004).Conclusion. Burdened antenatal and neonatal medical history has negative effect on the morphogenesis of the urinary system organs and creates conditions for early nephropathies development during the first months of life.
Publisher
Paediatrician Publishers LLC
Subject
Pediatrics, Perinatology and Child Health
Reference26 articles.
1. Zdravoohranenie v Rossii. 2021: Statistical compendium. Rosstat. Moscow; 2021. 171 p. (In Russ). https://rosstat.gov.ru/storage/mediabank/Zdravoohran-2021.pdf. Ссылка активна на 20.06.2022.
2. Order of the Ministry of Health of the Russian Federation dated August 10, 2017 No. 514н “O Poryadke provedeniya profilakticheskikh meditsinskikh osmotrov nesovershennoletnikh”. (In Russ). https: https://base.garant.ru/71748018. Ссылка активна на 20.06.2022.
3. Kaspar CD, Bholah R, Bunchman TE. A Review of Pediatric Chronic Kidney Disease. Blood Purif. 2016;41(1-3):211–217. doi: https://doi.org/10.1159/000441737
4. Chesnaye NC, van Stralen KJ, Bonthuis M, et al. Survival in children requiring chronic renal replacement therapy. Pediatr Nephrol. 2018;33(4):585–594. doi: https://doi.org/10.1007/s00467-017-3681-9
5. Styazhkina SN, Chernenkova ML, Khamitova AR, Miroshevskaya EP. The condition of the placenta in extragenital pathology (gestational pyelonephritis). StudNet. 2021;(5):1–8. (In Russ).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献