Author:
Vetlugina T. P.,Lobacheva O. A.,Al'perina E. L.,Zhukova E. N.,Semke A. V.,Nikitina V. B.,Cheido M. A.,Idova G. V.
Abstract
Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.
Publisher
Paediatrician Publishers LLC
Cited by
5 articles.
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