Protocol of observation, examination and antibacterial therapy of newborns with suspected and/or confirmed neonatal infection

Abstract

Background. One of the causes of early neonatal death in Russia and the world is infection. In recent years, in our country, the infectious diagnosis in 16–25% of cases was the main one among newborns who died in the first 168 hours of life. According to population studies from different countries, the cumulative incidence of neonatal sepsis is 22 cases per 1,000 live births, and mortality ranges from 11 to 19%. According to the data, timely diagnosis and appointment of etiotropic treatment, in most cases of antibacterial therapy (ABT), are crucial in the outcome of neonatal infection. However, in the Russian Federation, as in most other countries, there are no uniform protocols and Guidelines on this issue. Thus, the only solution to this problem is to create local protocols based on modern evidence base and at the same time corresponding to the microbial flora and logistical capabilities of a particular medical organization. The article presents the local protocol of the Yekaterinburg Clinical Perinatal Center (ECPC) “Protocol of observation, examination and antibacterial therapy of newborns with suspected and/or confirmed neonatal infection”, developed by the staff of the ECPC taking into account international conciliation documents, data from randomized clinical trials and meta-analyses, as well as the specifics of the perinatal center.