The Role of Molecular Genetic Studies in Current Oncology

Abstract

Genetic information, both inherited and tumor-specific, is becoming an increasingly important factor in the implementation of therapeutic strategies in oncology, providing an individual approach to each patient. Every year, an increasing number of achievements in medical genetics are introduced into oncological practice in the form of laboratory tests, diagnostic panels and practical recommendations. The article provides a brief overview of the results of genetic studies performed at the Federal National Medical Research Centre for Oncology of the Ministry of Health of the Russian Federation from the beginning of their implementation in 2013 to the present day. We have demonstrated not only testing data within the framework of clinical recommendations, but also an analysis of the search for new genetic, epigenetic and proteomic markers, which seem promising for the development of new target drugs, diagnostic and prognostic test systems. We believe that the model of interaction between a researcher and an oncologist used in our center allows us to shorten the path from a scientific hypothesis to the creation and implementation of innovative technologies.