Dermatologic toxicity of high doses of tiothepa in children. Case report-Reference-Cited by-同舟云学术

Dermatologic toxicity of high doses of tiothepa in children. Case report

Published:2023-05-03 Issue:2 Volume:20 Page:134-140
ISSN:2500-3089
Container-title:Pediatric pharmacology
language:
Short-container-title:Pediatr. farmakol.

Author:

Aliev Teimur Z.¹^ORCID,Potemkina Tatiana I.¹^ORCID,Belysheva Tatiana S.¹^ORCID,Valiev Timur T.¹^ORCID,Sergeenko Karina A.¹^ORCID,Kostareva Irina A.¹,Kudaeva Lana M.²^ORCID,Machneva Elena B.³^ORCID,Ushakova Tatiana L.⁴^ORCID,Polyakov Vladimir G.⁵^ORCID,Kirgizov Kirill I.¹^ORCID,Varfolomeeva Svetlana R.¹^ORCID

Affiliation:

1. N.N. Blokhin National Medical Research Center of Oncology, L.A. Durnov Research Institute of Pediatric Oncology and Hematology

2. A.I. Yevdokimov Moscow State University of Medicine and Dentistry

3. N.N. Blokhin National Medical Research Center of Oncology, L.A. Durnov Research Institute of Pediatric Oncology and Hematology; Russian Children’s Clinical Hospital of Pirogov Russian National Research Medical University

4. N.N. Blokhin National Medical Research Center of Oncology, L.A. Durnov Research Institute of Pediatric Oncology and Hematology; Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Public Health of the Russian Federation

5. N.N. Blokhin National Medical Research Center of Oncology, L.A. Durnov Research Institute of Pediatric Oncology and Hematology; Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Public Health of the Russian Federation; Pirogov Russian National Research Medical University

Abstract

Hematopoietic stem cell transplantation (HSCT) is a treatment modality for a number of severe malignant and non-neoplastic diseases. Autologous hematopoietic stem cell transplantation (auto-HSCT) improves outcomes in patients with solid and hematological malignancies. Skin lesions at the auto-HSCT stage are quite common and represent an important diagnostic and therapeutic problem. The most significant causes of skin lesions in auto-HSCT are drug toxicity, infectious and viral lesions. Each of the complications can manifest itself to varying degrees as well as combine with others, having a significant negative on the patient’s condition, posing a threat to the patient’s life in severe cases.

Publisher

Paediatrician Publishers LLC

Subject

Pulmonary and Respiratory Medicine,Pediatrics, Perinatology and Child Health

Reference16 articles.

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