Author:
Köksal Ekrem,Ulutaş Yakup,Şimşek Samed,Bayraktar aha,Altay Ahmet,Çatır Mustafa,Demirtaş İbrahim,Tüfekçi Ali Rıza,Kandemir Ali,Alp Cemalettin,Alemdar Mohammed B. Anwer Alemdar,Akşit Hüseyin
Abstract
Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.
Subject
Organic Chemistry,Plant Science,Drug Discovery,Pharmacology
Cited by
3 articles.
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