Assessing testicular function in paraquat poisoning and Vitamin E and C Amelioration in Rats

Abstract

Paraquat is a poisonous chemical used for weed control. This study showed the impact of vitamin E and C on fasting lipid profile in paraquat prompted toxicity in rats. Exactly 180 rats were divided into four groups—A, B, C, and D— each group having three subgroups (0, VE, and VEC) of 15 rats each. B, C, and D were test groups, while A the control group. For three months, B0, C0, and D0 received treatments of 0.02g, 0.04g, and 0.06g of paraquat, twice every two weeks, A0 did not. BVE, CVE and DVE were treated in increasing dosages of paraquat and treated with 500mg of vitamin E weekly for three months. AVE had vitamin-E treatment. BVEC, VEC and DVEC were treated in rising dosages of paraquat, following 500mg of vitamin-E and 2000mg/dl of L-ascorbic acid weekly for three months. Vitamin E and C were treatments for AVEC. Oral treatment was used for all treatments. B0, C0, A0 and D0 subgroups were sacrificed and samples collected for male gonadal hormones. The findings demonstrated that there was no significant effect on male gonadal hormone levels after paraquat dose-dependent poisoning and no significant difference in male gonadal hormone levels after the vitamin treatment.