Author:
Vrkic Ana K.,O'Hair Richard A. J.,Foote Simon
Abstract
The gas-phase fragmentation reactions of the
[M–H]– ions derived from all 64
trinucleotides and 16 isomeric tetranucleotides each containing adenine,
thymine, guanine and cytosine were examined using multistage mass spectrometry
(MS/MS and MS3) collision-induced dissociation in an
ion trap mass spectrometer. The initial fragmentation pathway involved neutral
base loss predominantly from the 5´ terminus, along with minor 3´
and internal base loss in the order A > T > G > C to form
[M–H–BH]–
‘non-sequence’ ions. The resultant
[M–H–BH]– ions often
fragment via intramolecular proton transfer with concomitant cleavage of the
3´ C–O phosphodiester bond to yield an ion–molecule complex,
which undergoes either direct dissociation or proton transfer to yield the
w-type or (a–B)-type ‘sequence’ ions respectively.
Cited by
8 articles.
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