Abstract
In general, electrophilic
alkylation of purin-8-ones takes place at the same sites as protonation.
Exceptions are observed only for 3-methyl derivatives, in which cation
formation involves N9, whereas methylation proceeds both at position 1 and 9.
This dichotomy of alkylation is ascribed to steric interference between 3- and
9-methyl substituents.
Cited by
2 articles.
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1. References;Chemistry of Heterocyclic Compounds: A Series Of Monographs;2008-01-02
2. ChemInform Abstract: METHYLATION OF PURIN-8-ONES;Chemischer Informationsdienst;1979-08-21