Author:
Lam Pik Ling,Yuen Marcus Chun Wah,Kan Chi Wai,Wong Raymond Siu Ming,Cheng Gregory Yin Ming,Lam Kim Hung,Gambari Roberto,Kok Stanton Hon Lung,Chui Chung Hin
Abstract
Chitosan microcapsules containing calendula oil are prepared by a simple coacervation method. The results show that the performance of the microcapsules, including encapsulation efficiency and particle size, is affected by the change of various processing parameters of microcapsule manufacture. Under the optimal parameter combinations: the chitosan concentration is 1.5 % w/v; the core/wall ratio is 0.1 g mL–1; the stirring speed is 1200 rpm; and the pH value is 10. The compositions and surface morphology of the microcapsules are examined using scanning electron microscope and FTIR spectroscopy. The in vitro cytotoxicity evaluation demonstrates that the microcapsules exhibit no significant cytotoxic effects on human keratinocytes. The in vivo toxicology analysis on mice proves that the microcapsules do not exert any significant necrosis to the liver. It is suggested that our microcapsules could be used as a safe drug carrier both topically and orally.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献