Synthesis, Structures, and Conformations of Linked Bis-Glyoxylamides Derived from Bis-Acylisatins

Abstract

A series of bis-glyoxylamides possessing hydrophobic alkyl chains was successfully synthesised by ring opening of bis-acylisatins with amines or amino acid alkyl esters. The crystal structures revealed the interplay of intra- and intermolecular interactions (NH···O and C=O···C=O interactions) and the conformations of these long molecules.