Author:
Cannon JR,Croft KD,Matsuki Y,Patrick VA,Toia RF,White AH
Abstract
The major alkaloid of a
Fijian Melodinus
sp. (family Apocynaceae) has been identified as (+)-scandine (1). The crystal structure and absolute
configuration of the acetone solvate of (+)-scandine hydrobromide have been determined by X-ray diffraction; diffractometer data at 295 K were refined by block diagonal
least squares to a residual of 0.037 (2657 'observed' reflections). Crystals of
the hydrobromide are monoclinic, P21, a 9.496(3), b 14.561(5), c 9.339(3) �,
β 115.39(2)�, Z 2. Although the cations of
(+)-scandine hydrobromide
and (+)-N-methylmeloscine
bromide have the same skeleton and the same absolute configuration, they have
different conformations; this appears to be due to the steric effect of the N-methyl group in the latter cation.
Cited by
26 articles.
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