Abstract
Context Anticoagulants have been used in New Zealand for decades, but few data are available on the sustainability of these toxins for rodent control. It is important to regularly monitor for resistance in long-term brodifacoum-use areas and establish a database for future references. Aims This study aimed to estimate the effective dose (ED50) of brodifacoum for ship rats from an area of New Zealand with no history of brodifacoum use, in order to establish a blood-clotting response test for assessing resistance in rodent populations from other areas. Methods A ranging study was conducted whereby successive groups of ship rats were administered brodifacoum doses that were increased or decreased progressively, until an International Normalised Ratio (INR) of 3.6 was reached. Linear regression was used to model the relationship between dose and INR, and ED50 dose was estimated using the resulting model. Results None of the rats appeared susceptible to brodifacoum at previously reported LD50 exposures for this species. The ED50 of brodifacoum was estimated to be 2.88 mg/kg for males and 3.81 mg/kg for females. These values are 6–8 times greater than the previously published lethal dose values for ship rats in New Zealand. Conclusions Blood-clotting inhibition was detected in the rats only following high doses of brodifacoum, which may indicate resistance within the sampled population. Implications Relatively low susceptibility, or resistance, to brodifacoum in New Zealand ship rats may be mediated by spatial connections between areas with different histories and patterns of anticoagulant rodenticide use.
Subject
Management, Monitoring, Policy and Law,Ecology, Evolution, Behavior and Systematics
Reference59 articles.
1. The calculation of LD50 using probit analysis.;The FASEB Journal,2013
2. Coumatetralyl resistance of infesting oil palm plantations in Indonesia.;Ecotoxicology,2013
3. Barron M, Griffiths J, Thomson C, Perry M, Clarke D, Sweetapple P (2014) How rapidly do rat populations recover after control with 1080? Kararehe Kino Issue 23. Manaaki Whenua, New Zealand.
4. A systematic approach to evaluating and ranking the relative animal welfare impacts of wildlife control methods: poisons used for lethal control of brushtail possums () in New Zealand.;Wildlife Research,2016
5. The warfarin resistance problem in England and Wales.;Schriftenreihe des Vereins fur Wasser-, Boden- und Lufthygiene,1968
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