Abstract
The encephalitogenic
nonapeptide Phe1-Ser2-Trp3-Gly4-Ala5-Glu6-Gly7-Gln8-
Lys9 and its [D-Ala5] analogue have been studied in
aqueous solution by 13C n.m.r. spectroscopy. The resonances of all
the carbons have been assigned and their pH profiles measured. The expected
conformational differences are indicated by only subtle differences in
long-range pH titration shifts. The spin-lattice relaxation times T1
of all the protonated carbons of the [L-Ala5] nonapeptide have been
measured at 25°C. Analysis of these data in terms of effective correlation
times for side-chain mobilities suggests restricted motions for the side chains
of Glu6 and Gln8 and the aromatic rings of Phe1
and Trp3.
Cited by
8 articles.
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