Author:
Griffiths Rebecca,Wong W. Wei-Lynn,Fletcher Stephen P.,Penn Linda Z.,Langler Richard F.
Abstract
Some disulfides have previously been shown to possess antifungal and/or antileukaemic activity. Importantly, this cytotoxicity can be selective. We have previously shown that a subset of these compounds does not block the proliferative potential of normal, non-transformed cells. Based on these results and proposed mechanisms of action, a new set of structurally modified organosulfur compounds, including α-substituted disulfides and a thiosulfonate ester, have been prepared and evaluated for their potential as antileukaemic agents. Compounds were screened for antiproliferative activity against a panel of human cells derived from acute lymphocytic and acute myelogenous leukaemia, as well as non-transformed cells. We have identified five new disulfides and a thiosulfonate that can trigger tumour cells to undergo cell death by an apoptotic mechanism in a sensitive and specific manner.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. S
‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent;ChemMedChem;2020-01-16
2. Oxidative stress-mediated antiproliferative effects of furan-containing sulfur flavors in human leukemia Jurkat cells;Food Chemistry;2015-08
3. Regiocontrolled Synthesis of Ring-Fused Thieno[2,3-c]pyrazoles through 1,3-Dipolar Cycloaddition of Nitrile Imines with Sulfur-Based Acetylenes;European Journal of Organic Chemistry;2010-09-28
4. Characterization of the apoptotic response of human leukemia cells to organosulfur compounds;BMC Cancer;2010-07-02
5. The Variable Strength of the Sulfur–Sulfur Bond: 78 to 41 kcal – G3, CBS‐Q, and DFT Bond Energies of Sulfur (S
8
) and Disulfanes XSSX (X = H, F, Cl, CH
3
, CN, NH
2
, OH, SH);European Journal of Inorganic Chemistry;2009-03-23