Author:
Novaro V.,Jawerbaum A.,Faletti A.,Gimeno M. A. F.,González E. T.
Abstract
In the process of embryo implantation in the rat, both nitric oxide and
prostaglandins act as vascular and myometrial regulators. The aim of the
present work was to evaluate the effect of diabetes on the synthesis of both
agents during embryo implantation. In diabetic rats, uterine activity of the
enzyme nitric oxide synthase and prostaglandin E production were increased
during peri-implantation compared to the control group
(P < 0·05 and P <
0·001, respectively). Both parameters showed a prolonged increase in
temporal profile during peri-implantation days. Local production of nitric
oxide and prostaglandin E in the implantation sites was higher in diabetic
rats (P < 0·05), but the intersite : site
ratio was similar to that of the control group. On the other hand, the
implantation rate and the timing of the beginning of this process were not
altered in the diabetic group. These results suggest that the vasoactive
modulators of the implantation process, nitric oxide and prostaglandins, are
increased in this diabetic pathology, and that this increase is probably
functioning as a compensatory mechanism, so as to allow an unaltered rate of
embryo implantation in this model.
Extra keyword: diabetes mellitus.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
12 articles.
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