Author:
Kowalewski A,Strekowski L,Szajda M,Walenciak K,Brown DJ
Abstract
The reaction of 5-bromo-N,N-dimethylpyrimidin-2-amine (1a) with butyllithium gives N,N,N',N'-tetramethyl-4,5'-bipyrimidine-2,2'-diamine
(2a). The known 4',6-dimethoxy derivative (3a) of this gives only 2,2'-bis(dimethylamino)-6-methoxy-4,5'-bipyrimidin-4'-one (4) on
attempted aminolysis by 2-dimethylaminoethylamine,
but the corresponding bismethylthio substrate (3b)
does undergo regular aminolysis at the 4'-position to
give the required product (34.2,2',4',6-Tetrakismethylthio-4,5'-bipyrimidine (5a)
undergoes similar aminolysis, first at the 4'- and
then at the 2'-position, to give the appropriate amines (5b) and (5c).
Structures are confirmed by n.m.r. and mass spectral studies. The products
showed little activity as amplifiers of phleomycin.
Cited by
14 articles.
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