Author:
Badger GM,Ennis BC,Matthews WE
Abstract
The intermediate adduct (e.g. III) formed
in Skraup and Doebner-Miller reactions has the nature of a Mannich base. It has
now been prepared from o-nitroaniline, formaldehyde, and methyl ethyl ketone by
the Mannich reaction. It has been cyclized to 3,4-dimethyl-8-nitroquinoline
under acidic oxidizing conditions; but it is not cyclized by neutral oxidants,
nor by non-oxidizing acids or Lewis acids.
Cited by
12 articles.
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