N-(Carboxymethyl)-N-[2-(2,6-diisopropylphenyl)amino]-2-oxoethylglycine and analogues: Synthesis and characterization

Abstract

N-(Carboxymethyl)-N-[2-(2,6-diisopropylphenyl)amino]-2-oxoethylglycine (DIS-IDA)* (2a) and two analogues have been successfully synthesized. The synthesis involved a modified one-pot reaction with specific reaction conditions to maximize yields. A general procedure for the isolation of the products has been set out and the stability of compounds (2) is briefly discussed. Characterization is reported with a view for use with 99mTc as radiopharmaceuticals.