The chemistry of pyrrolic compounds. XLVII. The synthesis of a possible biogenetic precursor of haem a and its relationship to the prosthetic group ofmyeloperoxidase and to cryptoporphyrin a-Reference-Cited by-同舟云学术

The chemistry of pyrrolic compounds. XLVII. The synthesis of a possible biogenetic precursor of haem a and its relationship to the prosthetic group ofmyeloperoxidase and to cryptoporphyrin a

Published:1981 Issue:4 Volume:34 Page:871
ISSN:0004-9425
Container-title:Australian Journal of Chemistry
language:en
Short-container-title:Aust. J. Chem.

Author:

Clezy PS,Fookes CJR

Abstract

The synthesis of 18-demethyl-18-formylprotoporphyrin dimethyl ester is described and the role of this compound as an intermediate in the biosynthesis of haem a is considered. A possible relationship between a compound of this structure and the prosthetic group of myeloperoxidase is discussed. The cryptoporphyrin a fraction of ox heart extracts has been reexamined and shown to consist of a mixture of Spirographis porphyrin and its isomer which presumably arise from the in vitro oxidation of the vinyl groups in protoporphyrin.

Publisher

CSIRO Publishing

Subject

General Chemistry

Link

http://www.publish.csiro.au/CH/pdf/CH9810871

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