Prevalence of human herpesvirus-8 among HIV-infected patients, intravenous drug users and the general population in Iran

Author:

Kakavand-Ghalehnoei Rezvan,Shoja Zabihollah,Najafi Alireza,Mollahoseini Mostafa Haji,Shahmahmoodi Shohreh,Marashi Sayed Mahdi,Nejati Ahmad,Jalilvand Somayeh

Abstract

Studies looking at the frequency of human herpesvirus-8 (HHV-8) among Iranian blood donors have produced conflicting results. The aim of this study was to investigate the prevalence of HHV-8 DNA by using polymerase chain reaction methods among 168 healthy individuals, 60 intravenous drug users and 100 HIV-infected patients from Iran. The prevalence of HHV-8 was significantly higher among intravenous drug users (13.3%) compared with the general population (3.6%; P = 0.017). The HHV-8 genome was mostly detected among intravenous drug users who displayed high-risk sexual behaviours. Moreover, the HHV-8 genome was also detected in 8% of HIV-infected patients. The present study findings support the likelihood that the transmission of HHV-8 is via a sexual route in the Iranian population.

Publisher

CSIRO Publishing

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

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