Author:
Inglis AS,Nicholls PW,Roxburgh CM
Abstract
The phenylthiohydantoins (PTHs) derived from amino acids were hydrolysed
in boiling hydriodic acid for 24 hr. Good yields of free amino acids were obtained for
all PTH derivatives except methionine. In contrast to hydrolysis with hydrochloric
acid, hydrolysis with hydriodic acid converts PTH-threonine, PTH-serine, and
PTH-tryptophan respectively to oc-amino-n-butyric acid, alanine, and a mixture
(approx. 2: 1) of glycine and alanine. This procedure provides a useful adjunct to
thin-layer chromatography and ultraviolet spectroscopy for quantitative identification
of the PTH derivative.
Subject
Developmental Biology,Endocrinology,Genetics,General Materials Science,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,General Medicine,Biotechnology
Cited by
46 articles.
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