Purine studies. XVII. The synthesis of 2-substituted 6,9-Di- and 6,8,9-Tri-methylpurines as amplifiers of phleomycin
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Published:1975
Issue:11
Volume:28
Page:2553
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ISSN:0004-9425
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Container-title:Australian Journal of Chemistry
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language:en
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Short-container-title:Aust. J. Chem.
Author:
Bhushan K,Brown DJ,Lister JH,Stephanson LG,Yoneda F
Abstract
2-(6?,8?,9?-Trimethylpurin-2?-ylthio)acetamide
(1e) and analogous N- substituted acetamides are prepared by treatment of
6,8,9- trimethylpurine-2-thione (3a) with an appropriate 2- chloroacetamide.
6,9-Dimethyl-2-(piperidin-1?-yl)purine (In) and some 2- polymethyleneamino
homologues are made by initial amination of 2- chloro-4-methyl-6-methylamino-5-nitropyrimidine
(2b) followed by reduction of the nitro group and final cyclization with formic
acid. Such purines enhance the lethal effect of phleomycin on Escherichia coli
cultures.
Publisher
CSIRO Publishing
Subject
General Chemistry
Cited by
15 articles.
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1. References;Chemistry of Heterocyclic Compounds: A Series Of Monographs;2008-01-02
2. References;Chemistry of Heterocyclic Compounds: A Series Of Monographs;2008-01-02
3. References;Chemistry of Heterocyclic Compounds: A Series Of Monographs;2008-01-02
4. Heterocyclic amplifiers of phleomycin;Medicinal Research Reviews;1982-04
5. Purine analogues as potential chemotherapeutic agents. III;Journal of Heterocyclic Chemistry;1982-01