Author:
Robinson A. J.,Jackson R.,Kerr P.,Merchant J.,Parer I.,Pech R.
Abstract
The history of myxoma virus, its use in Australia as a mortality agent and the
development of the virus as a vector for controlling fertility in wild rabbit
populations in Australia is reviewed. Myxoma virus recombinants have been
constructed to express model antigens. Four potential insertion sites in the
genome have been identified and two have been used to construct single and
double recombinant viruses expressing
Escherichia colienzymes β-galactosidase and
β-glucuronidase. Another recombinant expressing an influenza virus
haemagglutinin gene (A/PR8/34) induced high and sustained antibody
responses following intradermal inoculation in rabbits. To demonstrate the
potential of introducing a recombinant virus into wild rabbit populations, a
virus containing a natural deletion was released at four field locations.
Preliminary analysis of the data has shown that the introduced virus spread
well on 3 of the 4 locations. The steps being taken to address the ethical and
safety implications of the introduction of a recombinant virus into the field
are discussed.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
27 articles.
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