Abstract
Progesterone is essential for the establishment and maintenance of pregnancy.
The discovery of antagonists of progesterone offered the possibility of
developing new methods of fertility regulation. It was very quickly
demonstrated that antigestogens would induce bleeding in early pregnancy, and
mifepristone in combination with a prostaglandin is used as a method of
abortion in several countries. Mifepristone will also inhibit ovulation,
prevent implantation and induce menstrual bleeding at the time of expected
menses. However, the development of these contraceptive uses of antigestogens
has been inhibited by political and ethical controversy surrounding abortion.
Surely the time has come to dissociate the ongoing debate about the ethics of
abortion from the method so that the full therapeutic potential of this class
of drugs can be exploited fully.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
8 articles.
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