Abstract
The metabolism of two purines, which enhance the antibiotic activity of
phleomycin in vitro, has been
followed in mice. 2,9-Dimethyl-8-methylthiopurine (1c) gave mainly
2,9-dimethyl-8-methylthiopurin-6-one (2; R = SMe) and the corresponding sulphoxide (2; R = SOMe). In
contrast, 2-carbamoylmethylthio-6,9-dimethylpurine (1d) gave 2-carbamoylmethylthio-6,9-dimethylpurin-8-one
(5; R1 = SCH2CONH2, R2 = Me)
accompanied in the urine by unchanged material (1d). The identity of each
metabolite was confirmed by unambiguous synthesis.
Cited by
15 articles.
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