Alkylations of Tricarbonylcyclohexadienyliron Salts with Mixed Alkylcuprate Reagents

Abstract

A study of the reaction between mixed alkylcuprate reagents [Li(R1R2Cu)] with tricarbonylcyclohexadienylironsalts (1) has shown that, when R2 = SPh, alkylation of (1) may be achieved in moderate to good yields for R1 = Pri, Bu and But. Only minor yields are obtained for R1 = Me and CH2=CH, the main reaction being thiophenoxylation, but for these substituents alkylation is achieved with the dialkylcuprate. The regioselectivity of the reaction has been studied for a number of cuprate reagents.