Abstract
The synthesis of a number
of new N,N'-dialkyl barbituric acids
is reported. The compounds are ethyl hexobarbital, the diethyl derivatives of
secobarbital and cyclobarbital, the chloroethyl derivatives ofmephobarbital and
hexobarbital, and the bis(chloroethy1) derivatives of barbital, cyclobarbital,
secobarbital, butobarbital and secbutobarbital.In addition, several new N-alkylated derivatives of some common
anticonvulsant drugs are included. These are ethyl glutethimide, the
chloroethyl derivatives of ethosuximide, glutethimide, peganone, mephenytoin
and diphenylhydantoin. Infrared, N.M.R., mass spectral and gas chromatographic retention
data are given.
Cited by
10 articles.
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