Abstract
Several N-protected
DL-kynurenine derivatives have been converted into 3-substituted 3,4-dihydro-1H-1-benzazepine-2,5-diones
by thermal cyclization. This reaction was found to proceed less readily than
the analogous formation of 1,4-benzodiazepine-2,5-diones from o- aminobenzoylamino
acids. The incidence of specific peptide bond cleavage involving these
cyclizations was investigated with model compounds.
Cited by
13 articles.
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1. Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from Aspergillus nanangensis Involves an Unusual l-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization;Journal of the American Chemical Society;2020-03-17
2. Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors;Enzyme Inhibitors Series;2006-10-25
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