Author:
Collins DJ,Mollard S,Rose N,Swan JM
Abstract
A series of 2-(N-dialkylamino)ethyldiphenylphosphine
oxides and sulphides was prepared by the addition of a secondary amine to
diphenylvinylphosphine oxide, or the phosphine sulphide, respectively. Similarly,
a series of 2-(N-dialkylamino)propyldiphenylphosphine oxides was prepared from
diphenylprop-1-enylphosphine oxide, or from diphenylprop-2-enylphosphine oxide
which isomerized under the reaction conditions. Reduction of the 2-(N-dialkylamino)propyldiphenylphosphine
oxides with trichlorosilane, and oxidation of the phosphines with sulphur,
afforded the corresponding phosphine sulphides. ��� None of the compounds showed significant
analgesic activity.
Cited by
28 articles.
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