A Total Synthesis of the Marine Alkaloid Ningalin B from (S)-Proline-Reference-Cited by-同舟云学术

A Total Synthesis of the Marine Alkaloid Ningalin B from (S)-Proline

Published:2009 Issue:7 Volume:62 Page:683
ISSN:0004-9425
Container-title:Australian Journal of Chemistry
language:en
Short-container-title:Aust. J. Chem.

Author:

Hasse Katrin,Willis Anthony C.,Banwell Martin G.

Abstract

The title alkaloid 1 has been synthesized from (S)-proline (2) using a sequence of reactions involving oxidative bromination (of 2), N-alkylation, Suzuki–Miyaura cross-coupling, and bromination steps.

Publisher

CSIRO Publishing

Subject

General Chemistry

Link

https://www.publish.csiro.au/CH/pdf/CH09158

Reference16 articles.

1. Ningalins A−D: Novel Aromatic Alkaloids from a Western Australian Ascidian of the Genus Didemnum

2. Total Synthesis of Ningalin B Utilizing a Heterocyclic Azadiene Diels−Alder Reaction and Discovery of a New Class of Potent Multidrug Resistant (MDR) Reversal Agents

3. Multidrug resistance reversal activity of key ningalin analogues

4. Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

5. Short and flexible route to 3,4-diarylpyrrole marine alkaloids: syntheses of permethyl storniamide A, ningalin B, and lamellarin G trimethyl ether

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