Abstract
The preparation of
2,2,4,6-tetramethyldihydropyridine by the reaction of acetone and ammonia at
temperatures of 100-180 �C. has been studied; using an alkaline catalyst at 120
�C. for 3 hr, a yield of over 60 per cent. can be obtained. This dihydro-pyridine
is identical with the product obtained by Matter (1948) in the pyrolysis of
2,2,4,4,6-pentamethyltetrahydropyrimidine Possible mechanisms for its formation
are discussed. Catalytic hydrogenation over Raney nickel leads to
tetramethyl-piperidine, while with palladium a partial reduction product,
formulated as 2,2,4,6-tetramethyl-2,3,4,5-tetrahydropyridine is obtained ; the
chemistry of these reduction products has been examined.
Cited by
10 articles.
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