Vault Isomerization and its Application to the Synthesis of a Dideoxydysoxysulfone Precursor

Abstract

Novel silica-induced controlled disproportionation of α-mercaptosulfones produces α-mercapto α′-sulfonyl sulfides. Its discovery and exploitation, as the heart of a new process – vault isomerization – permits the elaboration of a more efficient synthesis of a previously described synthetic precursor.