Abstract
Copper(II) ions catalyse the hydrolysis of
glycylglycine in the pH range 3.5-6. The pH-rate profile has a maximum at pH
4.2, due to the formation of a complex CuGlyGly+. The decrease in
rate at higher pH values is associated with the production of catalytically
inactive CuGlyGly complexes produced by the ionization of the peptide hydrogen
atom. The mechanism of the reaction is discussed and its possible biological
significance considered.
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