Author:
Faizi Shaheen,Siddiqui Bina Shaheen,Saleem Rubeena,Akhtar Farzana,Khan Khursheed Ali,Khan Shakeel Ahmed,Siddiqui Salimuzzaman,Parvez Masood,Choudhary M. Iqbal
Abstract
Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and
m-nitrobenzaldehyde afforded 7-(α-hydroxy-
m-nitrobenzyl)quinolin-8-ol (2), which is an unusual
Mannich reaction product. The structure of (2) was determined by spectroscopic
and single-crystal X-ray diffraction studies. Preliminary antimicrobial
screening showed that (1) and (2) have activity against a large number of
Gram-positive and Gram-negative bacteria.
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