Author:
Cambie RC,Denny WA,Klose TR,Mander LN
Abstract
Methods for the conversion
of 12-hydroxypodocarpa-8,11,13-trien-19-oic acid (1)
into the α,β-unsaturated ketones (6) and
(7) have been investigated. Lithium in liquid ammonia reduction of the ester
(19) and the hydroxy acid (24) with concomitant decarboxylation gives moderate
yields of the desired products. The ketone (7) has also been prepared in
improved yield by a modification of Bible and Burtner's
method involving the intermediates (9), (35), (12), (16), (17), and (18).
Cited by
19 articles.
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