Could late-latent syphilis be treated with a single subcutaneous infusion of long-acting penicillin?

Author:

Hla Thel K.ORCID,Salman Sam,Kado Joseph,Moore Brioni R.,Manning Laurens

Abstract

Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion. Based on pharmacokinetic modelling from a Phase I study of subcutaneous infusion of high dose BPG (SCIP), we present its feasibility, safety and tolerability for treatment of syphilis in a single infusion. SCIP leads to more sustained penicillin concentrations above the desired target with less reported pain and reduced clinic visits.

Funder

CureKids New Zealand

Publisher

CSIRO Publishing

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5. Treatment completion with three-dose series of benzathine penicillin among people diagnosed with late latent and unknown duration syphilis, Maricopa County, Arizona.;Sex Transm Dis,2023

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