Signalling via glutamate and GLRs in Arabidopsis thaliana

Abstract

The genome of Arabidopsis thaliana (L. Heynh.) contains 20 coding sequences for homologues of animal ionotropic glutamate receptors. These glutamate receptor-like receptors act as sensors and mediators of a multitude of exogenous as well as endogenous signals and are found in all analysed plant species. Their molecular structure clearly indicates a function as integral membrane proteins with a ligand-gated ion channel activity. Altered gene expressions and the occurrence of mRNA splice variants confer a high flexibility on the gene as well as on the RNA level. An individual glutamate receptor of A. thaliana is able to bind two different ligands (most probable amino acids and their derivatives), whereas a functional receptor complex is likely to consist of four single proteins. These features enable an immense number of sensitivities against various local and temporal stimuli. This review encompasses the last 15 years of research concerning glutamate signalling and glutamate receptors in plants. It is aimed at summarising their major characteristics and involvements to obtain a broader and farer reaching perspective of these fundamental components of plant signal transduction.