Hormone Receptor Levels and Metabolic Activity in the Uterus of the Ewe: Regulation by Oestradiol and Progesterone

Abstract

Oestradiol and progesterone were administered alone or together in various combinations to different groups of ovariectomized ewes and several aspects of uterine and endometrial metabolism were determined. Levels of cytosol receptors for oestradiol and progesterone and metabolism of these steroids in whole uterus were measured, as well as mean cell content of RNA, rate of protein synthesis, tissue DNA concentration and alkaline phosphatase activity in the endometrium, uterine weight, and the amount of protein in uterine flushing.