Author:
Renner Jens,Kruszelnicki Irma,Adamiak Beata,Willis Anthony C.,Hammond Edward,Su Stephen,Burns Christopher,Trybala Edward,Ferro Vito,Banwell Martin G.
Abstract
Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.
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16 articles.
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