Simultaneous diversity-oriented synthesis of benzothiazoles and related diverse analogues by iodine-catalyzed intramolecular cyclization from identical substrates

Abstract

A facile oxidative cyclization of β-ketothioamides for the simultaneous formation of a compound library similar to natural product benzothiazole derivatives has been developed. The oxidative cyclization of β-ketothioamides resulted in the simultaneous formation of four classes of previously unknown benzothiazole derivatives. This chemistry’s versatility adds a valuable component to the methodology for obtaining benzothiazole derivatives.