Author:
Al-Hamood M. H.,Elbetieha A.,Bataineh H.
Abstract
The reproductive toxicity of trivalent and hexavalent chromium compounds was
investigated in male and female mice exposed to 1000 ppm chromium chloride and
potassium dichromate via their mother during gestational and lactational
periods.
Fertility was reduced in male offspring exposed to either trivalent or
hexavalent chromium compounds. Body weights and weights of testes, seminal
vesicles and preputial glands were reduced in trivalent-exposed male
offspring.
The exposure of female mice offspring to trivalent and hexavalent chromium
compounds delayed sexual maturation. Fertility was reduced in female offspring
exposed to either trivalent or hexavalent chromium compounds. The exposure of
female mice to hexavalent chromium compound reduced the number of
implantations and viable fetuses respectively. Body weight and weights of
ovaries and uteri were reduced in trivalent-exposed female offspring.
The results indicate that under our experimental conditions, the exposure of
male and female mice offspring to either trivalent or hexavalent chromium
compounds during gestational and lactational periods impair reproductive
functions and fertility in adulthood.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
46 articles.
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