Author:
Fujita T,Watanabe S,Suga K
Abstract
Lithium naphthalenide
reacts with carboxylic acids in the presence of diethylamine to give the α-anions
of lithium carboxylates. Reaction of these anions with various epoxides gives
the corresponding y-hydroxy acids in good yield. The γ-hydroxy acids easily
cyclize to give γ-butyrolactones.
Cited by
30 articles.
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5. A convenient one step synthesis of 2,4-dialkyl-2-hydroxy-alkyl-γ-butyrolactone using lithium naphthalenide;Journal of Applied Chemistry and Biotechnology;2007-05-29