Author:
Blair IA,Frith RG,Phillipou G,Seaborn CJ
Abstract
3β-Acetoxypregn-5-eno-18,20-lactone
has been converted into 3β,20β-dimethoxypregn-5-ene (6) by using
electrochemical deoxygenation of a C13 formyl intermediate as a key reaction. The electrochemicalreduction is also shown to
be applicable to multiple deuterium labelling of the C13 angular methyl group
in high isotopic purity.A facile preparation of 3β
-hydroxy-17α-methyl-D-homoandrost-5-en-17a-one (10) and its respective C18-2H3
analogue from the ether (6) is described.
Cited by
7 articles.
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