Novel 5-(3-(Substituted)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl Derivatives: Synthesis and Anticancer Activity-Reference-Cited by-同舟云学术

Novel 5-(3-(Substituted)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl Derivatives: Synthesis and Anticancer Activity

Published:2008 Issue:11 Volume:61 Page:864
ISSN:0004-9425
Container-title:Australian Journal of Chemistry
language:en
Short-container-title:Aust. J. Chem.

Author:

Liu Xin-Hua,Song Bao-An,Bhadury Pinaki S.,Zhu Hai-Liang,Cui Ping,Hou Ke-Ke,Xu Hong-Li

Abstract

Thirty novel 5-(3-(substituted phenyl)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl derivatives were synthesized and evaluated for their antitumour activity. The bioassays showed that the 2-fluorobenzoyl derivative 6ai, the 4-trifluoromethylbenzoyl derivative 6ah, and the 3-trifluoromethyl isoxazole derivatives (6ch and 6ci) were highly effective against PC-3 cells. The IC50 values of 6ah and 6ai against PC-3 cells were 1.5 and 1.8 μg mL–1, respectively.

Publisher

CSIRO Publishing

Subject

General Chemistry

Link

http://www.publish.csiro.au/CH/pdf/CH07395

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